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| Drug Metabolism & Disposition AdvertisementHome Articles Current Issue Fast Forward Latest Articles Special Sections Archive Information Instructions to Authors Submit a Manuscript FAQs For Subscribers Terms & Conditions of Use Permissions Editorial Board Alerts Alerts RSS Feeds Virtual Special Sections Feedback Submit Other Publications Drug Metabolism and Disposition Journal of Pharmacology and Experimental Therapeutics Molecular Pharmacology Pharmacological Reviews Pharmacology Research & Perspectives ASPET User menu My alerts Log in My Cart Search Search for this keyword Advanced search Other Publications Drug Metabolism and Disposition Journal of Pharmacology and Experimental Therapeutics Molecular Pharmacology Pharmacological Reviews Pharmacology Research & Perspectives ASPET My alerts Log in My Cart Search for this keyword Advanced Search Home Articles Current Issue Fast Forward Latest Articles Special Sections Archive Information Instructions to Authors Submit a Manuscript FAQs For Subscribers Terms & Conditions of Use Permissions Editorial Board Alerts Alerts RSS Feeds Virtual Special Sections Feedback Submit Visit dmd on Facebook Follow dmd on Twitter Follow ASPET on LinkedIn ASPET and Elsevier Partner to Publish the Society’s Journals DMD Marks Its 50th Anniversary with Celebration Collection Special Section on Perspective on Drug Metabolism and Disposition- Part 1 by DMD Associate Editors Special Section on Mechanism-Based Predictive Methods in Drug Discovery and Development - freely accessible through April 30, 2024 Pharmacology Awareness Week ASPET 2024 Annual Meeting New DMD Virtual Special Sections! 2023 DMD Gillette Award Winners 2023 DMD Top Reviewer 1 2 3 4 5 Latest Fast Forward Articles You have access Human Enteroid Monolayers: A Novel, Functionally-Stable Model for Investigating Oral Drug Disposition Christopher Arian , Eimear O Mahony , James W. MacDonald , Theo K Bammler , Mark Donowitz , Edward J. Kelly and Kenneth E. Thummel Drug Metabolism and Disposition May 14, 2024, DMD-AR-2023-001551; DOI: https://doi.org/10.1124/dmd.124.001551 You have access Mechanistic account of distinct change in organic anion transporting polypeptide 1B (OATP1B) substrate pharmacokinetics during OATP1B-mediated drug-drug interactions using physiologically-based pharmacokinetic modeling Pooja V. Hegde and Bridget L. Morse Drug Metabolism and Disposition May 13, 2024, DMD-AR-2024-001708; DOI: https://doi.org/10.1124/dmd.124.001708 You have access Pharmacokinetic/Pharmacodynamic assessment of the structural refinement of clopidogrel focusing on the balance between bioactivation and deactivation Dong Sun , Yingze Liu , Lin Zhu , Zhiping Xu , Yuyao Zhang , Haipeng Li , Huan Yang , Xia Cao and Jingkai Gu Drug Metabolism and Disposition May 10, 2024, DMD-AR-2024-001699; DOI: https://doi.org/10.1124/dmd.124.001699 You have access After fifty years of hepatic clearance models, where should we go from here? Improvements and implications for PBPK modeling K. Sandy Pang , Weijia Ivy Lu and Gerard J. Mulder Drug Metabolism and Disposition May 8, 2024, DMD-AR-2024-001649; DOI: https://doi.org/10.1124/dmd.124.001649 You have access The Metabolism and Disposition of Brepocitinib in Humans and Characterization of the Formation Mechanism of an Aminopyridine Metabolite Martin E Dowty , Ruolun Qiu , Alyssa Dantonio , Mark Niosi , Angela Doran , Amanda Balesano , Stephen W Wright , Gregory S. Walker and Raman Sharma Drug Metabolism and Disposition May 7, 2024, DMD-AR-2024-001750; DOI: https://doi.org/10.1124/dmd.124.001750 You have access Tissue-, region-, and gene-specific induction of microsomal epoxide hydrolase expression and activity in the mouse intestine by arsenic in drinking water Hui Li , Xiaoyu Fan , Xinxin Ding and Qing-Yu Zhang Drug Metabolism and Disposition May 7, 2024, DMD-AR-2024-001720; DOI: https://doi.org/10.1124/dmd.124.001720 View more published ahead of print articles About Drug Metabolism & Disposition DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression. Current issue Drug Metabolism and Disposition Vol. 52 , Issue 5 1 May 2024 Table of Contents Table of Contents (PDF) About the Cover Index by author Editorial Board (PDF) Front Matter (PDF) DMD is published continuously. Articles are added as they are ready and assigned to monthly issues. Check this site for new content or sign up for content alerts . EDITOR’S CHOICE ARTICLES FOR MAY 2024: Projections of Drug-Drug Interactions Caused by Time-Dependent Inhibitors of Cytochrome P450 1A2, 2B6, 2C8, 2C9, 2C19, and 2D6 Using In Vitro Data in Static and Dynamic Models CYP7A1 Gene Induction via SHP-Dependent or Independent Mechanisms can Increase the Risk of Drug-Induced Liver Injury Independently or in Synergy with BSEP Inhibition Most Cited Most Read Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes. Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes THE HUMAN INTESTINAL CYTOCHROME P450 PIE” DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC I /AUC) RATIOS In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model More... 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