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Home | Drug Metabolism & Disposition Skip to main content Advertisement Main menu Home Articles Current Issue Fast Forward Latest Articles Archive Information Instructions to Authors Submit a Manuscript FAQs For Subscribers Terms & Conditions of Use Permissions Editorial Board Alerts Alerts RSS Feeds Virtual Issues Feedback Other Publications Drug Metabolism and Disposition Journal of Pharmacology and Experimental Therapeutics Molecular Pharmacology Pharmacological Reviews Pharmacology Research & Perspectives ASPET User menu My alerts Log in My Cart Search Search for this keyword Advanced search Other Publications Drug Metabolism and Disposition Journal of Pharmacology and Experimental Therapeutics Molecular Pharmacology Pharmacological Reviews Pharmacology Research & Perspectives ASPET My alerts Log in My Cart Search for this keyword Advanced Search Home Articles Current Issue Fast Forward Latest Articles Archive Information Instructions to Authors Submit a Manuscript FAQs For Subscribers Terms & Conditions of Use Permissions Editorial Board Alerts Alerts RSS Feeds Virtual Issues Feedback Visit dmd on Facebook Follow dmd on Twitter Follow ASPET on LinkedIn ASPET's Journals Are Plan S Compliant Special Section on Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions Freely Accessible through Dec. 31 Dr. Xinxin Ding Chosen to Be Next DMD Editor Tatsuki Mochizuki SNPs Distant from AHREs Alter AHR-Regulated Gene Expression Plasma and Liver Protein Binding of GalNAc-Conjugated siRNA Canalicular ABC Transporters in HuH-7 Cells Tissue Drug Concentrations: Beyond the Free Drug Hypothesis 1 2 3 4 5 Latest Fast Forward Articles You have access Impact of plasma protein binding in drug clearance prediction: a database analysis of published studies and implications for in vitro in vivo extrapolation Laura Jane Francis , Brian Houston and David Hallifax Drug Metabolism and Disposition December 18, 2020, DMD-AR-2020-000294; DOI: https://doi.org/10.1124/dmd.120.000294 You have access Prediction of transporter-mediated drug-drug interactions and phenotyping of hepatobiliary transporters involved in the clearance of E7766, a novel macrocycle-bridged dinucleotide Rongrong Jiang , Andrew Hart , Laurette Burgess , Dae-Shik Kim , Weidong George Lai and Vaishali Dixit Drug Metabolism and Disposition December 18, 2020, DMD-AR-2020-000125; DOI: https://doi.org/10.1124/dmd.120.000125 You have access Aldehyde Oxidase Contributes to all- trans -Retinoic Acid Biosynthesis in Human Liver Guo Zhong , Chris J. Seaman , Erickson M. Paragas , Huanqing Xi , Karla-Luise Herpoldt , Neil King , Jeffrey P. Jones and Nina Isoherranen Drug Metabolism and Disposition December 18, 2020, DMD-AR-2020-000296; DOI: https://doi.org/10.1124/dmd.120.000296 You have access Evaluation of tissue stem cell derived human intestinal organoids, a physiologically relevant model to evaluate cytochrome P450 induction in gut David Michael Stresser , Jun Sun and Sarah W Wilson Drug Metabolism and Disposition December 18, 2020, DMD-AR-2020-000281; DOI: https://doi.org/10.1124/dmd.120.000281 You have access In vitro metabolism of slowly cleared GPR139 agonist TAK-041 using rat, dog, monkey and human hepatocyte models (HepatoPac): correlation with in vivo metabolism Amin Kamel , Stephen Bowlin , Natalie Hosea , Dimitrios Arkilo and Antonio Laurenza Drug Metabolism and Disposition December 3, 2020, DMD-AR-2020-000246; DOI: https://doi.org/10.1124/dmd.120.000246 You have access Impact of direction of transport on the evaluation of inhibition potencies of multidrug and toxin extrusion protein 1 (MATE1) inhibitors Asami Saito , Naoki Ishiguro , Masahito Takatani , Bojan Bister and Hiroyuki Kusuhara Drug Metabolism and Disposition December 1, 2020, DMD-AR-2020-000136; DOI: https://doi.org/10.1124/dmd.120.000136 View more published ahead of print articles About Drug Metabolism & Disposition DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression. Current issue Drug Metabolism and Disposition Vol. 49 , Issue 1 1 Jan 2021 Table of Contents About the Cover Index by author DMD is published continuously. Articles are added as they are ready and assigned to monthly issues. Check this site for new content or sign up for content alerts . EDITOR'S CHOICE ARTICLES FOR JANUARY: Regulation of Intestinal UDP-Glucuronosyltransferase 1A1 by the Farnesoid X Receptor Agonist Obeticholic Acid Is controlled by Constitutive Androstane Receptor through Intestinal Maturation EDITOR'S CHOICE ARTICLES FOR DECEMBER: In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability - open access Most Read Physiology of the Neonatal Gastrointestinal System PBPK Modeling for Clopidogrel and Its Active Metabolite Pharmacokinetics and Disposition of Biologics Metabolism and Disposition of Volanesorsen across Species Review of the Use of PBPK Modeling More... 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